"She continued to thrive as a businesswoman through enormous radical and social change, designing clothes for women fighting for liberation through the women's rights movement in the 1960s to empowering women today," the family said in a statement.
In the early 1970s Zampatti became one of the first designers to introduce swimwear into her collections in then socially conservative Australia. Born in Italy in 1942, before her family emigrated to Australia in 1950, Zampatti produced her first small fashion collection in 1965 before setting up Carla Zampatti Pty Ltd five years later.
"It is amazing what you can do with an incredible amount of youthful optimism and very little money," Zampatti told the Australian Associated Press in 2009.
A savvy businesswoman who opened dozens of boutiques across Australia, Zampatti held several directorships, and served as chairwoman of Australian public service broadcaster the Special Broadcasting Service.
"We have lost a truly great and inspirational Australian," Prime Minister Scott Morrison said in a statement, adding that Zampatti was not only a fashion industry icon but a pioneer as an entrepreneur and a champion of a multicultural approach.
"Her contribution to our nation will be timeless, just like her designs."
On Zampatti's online memorial page, a customer who identified herself only as Louise wrote, "It is true of every piece I wear from the CZ line-I feel confident, elegant and empowered....Thank you for the years of inspiration."
