The CLRI has licensed the technology to private small-scale entrepreneurs, who manufacture and supply native collagen membrane, reconstituted collagen membrane, and silver sulfadizene-loaded collagen to hospitals and clinics. Some is also exported.
Research into the structure of collagen started at the Madras University in the 1950s. Along with other world laboratories and scientists, an Indian scientist, G N Ramachandran, identified the structure of collagen and developed technology for its isolation and purification. CLRI scientists began research on reconstituting the purified collagen into different forms such as membranes, films, sponges and powder for biomedical applications.